Medicinal Chemistry and Toxicology
syllabus for first two weeks:
Update for September 14: Room
numbers have been added to the weekly schedule. Note that the Monday
start time has been moved to 10 AM!
Update for August 13:
The daily schedule listed below is correct. Some texts have been chosen:
Foye's Principles of
Medicinal Chemistry 5th ed., by Williams, Lemke, &
Foye, published by Lippincott Williams and Wilkens 2002
Studying a Study and Testing
a Test: How to Read the Medical Evidence 5th ed. by Richard
Riegelman published by Lippincott Williams and Wilkens 2004
The Discovery of Insulin
by Michael Bliss University Of Chicago Press; Reprint edition (October
0226058980 Any printing of this should be fine This will be the
first seminar book
Dreams by John Hoberman
University of California Press 2005 ISBN:
On you bookshelf you should also have a fairly current organic chem
text and a biochemistry -cell biology reference.
We will probably also do 1-2 of the recent critiques of the drug
industry. I am still undecided and am reading through the following
three: Powerful Medicines by
Jerry Alvorn, The Truth
About Drug Companies by Marica Angell, and Overdose by Jay Cohen. Each
is slightly different but there is also a lot of overlap. I'll let you
know when I decide.
INFORMATION AS OF MAY 23 2005
Medicinal Chemistry and Toxicology: Information for Academic Fair May
Faculty: James Neitzel, Lab I room 1022, 867-6463,
Enrollment options: 16 or 12 credits. (The 16 credit option includes a
laboratory component. The 12 credit option does not.)
Course Equivalencies likely given in medicinal chemistry, toxicology,
Required Student Preparation: Jr/Sr status, completion of at least 2
quarters organic chemistry, 2 quarters biochemistry, some molecular or
cell biology useful.
Texts: Have not yet been finalized. Will include medicinal chem text,
biostatistics, and possibly a toxicology text. You should have access
organic chemistry and biochemistry texts.
This program will examine the interactions between chemicals and
animals, particularly focusing on events at the cellular and molecular
level. A major emphasis will be on common cellular signaling pathways
altered by drug action. In addition, the importance of
structure-function relationships in examining the biological activity
of chemicals will be a common theme. Mathematical models for the
absorption, distribution, and elimination of pharmaceuticals will be
Toxic reactions to drugs and other chemicals will be examined, and the
biochemical mechanisms for the transformation and elimination of
foreign compounds will be covered. Current trends in research that are
allowing rapid drug discovery and testing will be included. The
statistical methods used to examine biomedical hypotheses will be
taught to assist in the understanding of primary research papers in
this field. Finally, historical case studies on the discovery,
development and regulation of selected drugs will be studied. Program
time will include lectures, seminars, laboratories, and student
presentations. This is an upper division program assuming students have
completed organic chemistry and biochemistry
Proposed Weekly Schedule:
Lecture/Workshop Seminar 2 E2107
Monday: 1-3 Computer Lab Lab 2
Tuesday: 10-12 Seminar; 1-3 Workshop Lab 1, 1040
Wednesday: 9-12 Lecture/Workshop Lab
Friday: 9-12, 1-4: Laboratory Lab
1, 2040/2046 (In addition, students will need to use
other time for instrument instruction.) Also, at least one all-program
Friday field trip (medicinal herb garden, biotech company.)
Proposed topics to be covered:
Effects of physical properties of chemicals (solubility, partition
coefficients, acid/base) on their biological effects.
Structure-activity relationships (configuration, conformation, polarity)
Adsorption, distribution, metabolism and excretion of xenobiotic
Mechanisms for toxicity (acute, carcinogenesis, developmental, genetic)
Endocrinology and physiology as needed
Historical origins and key experiments in the development of ideas
about drugs and toxins
Statistical methods commonly used in biomedical research, as used in
examples drawn from primary literature.
Current topics in drug development and toxicology, production
processes, economic/political linkages, regulations.
Examples of planned class case studies:
Pain control (opiates, NSAIDS, selective COX inhibitors)
Adrenergic/cholinergic receptors and autonomic nervous system
Antiviral and antiparasitic compounds
Steroid hormones, oral contraception, estrogen mimics
Validation and interpretation of drug screen results.
Each student will also research and present an individual case study on
a particular compound.
What will be done in the lab portion?
1. More advanced use of GC-MS. New topics would include sample prep and
cleanup from complex matrices, (esp. solid phase microextraction),
derivatization, quantitative methods, selective ion mode.
2. Measurement of drug affinity to a serum protein.
3. Conversion of organic compounds by an enzyme system (cytochrome P450
oxidation or monoamine oxidase) commonly seen in biotransformation
4. Simple toxicology model system (brine shrimp/bacteria) or Ames test
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Last modified: 23 May 05