Week 7

In relation to Dr Furlong's guest lecture, please see readings below for the organophosphate related toxicity and associated genetic polymorphisms: These pdf's deal with not only genetic variability and risk of organophosphate
exposure, but also cover risk of carotid artery disease and microbial
infection. Of the pdf's priority readings are the following: Ann-Rev-Med, Catalytic efficiency, Shih 1998, Holland 2006, Cole XG mouse and Devel-PharmGen.

Also attached is chapter 9 of the Asante-Duah book on acceptable/safe environmental exposure levels to complement Tuesday's lecture, and also chapter 5 of the Risk Assessment textbook that provides some basic structures for the equations involved in physiologically based pharmacokinetics (PBPK) models to complement Friday's workshop. We will look into simple models for back-calculating dose from urinary or blood levels of chemicals such as those reported in CDC's biomonitoring reports.

The links below are related to exposure in aircraft cabin air to some organophosphate compounds. Interesting context given that we all fly these days...

Channel 4 News, London


Channel 5, Seattle

First clip http://www.king5.com/video/?z=y&nvid=221600

Second clip http://www.king5.com/video/healthlink-index.html?nvid=228629

BBC News – Tom Symonds

House of Lords Air Travel Report


Risk Assess. Ch. 50001.pdf2.92 MB
Holland 2006.pdf141.4 KB
Bastaki 2006.pdf119.79 KB
Tujague 2006.pdf248.43 KB
Env Health Policy-Adv Connections.doc33.5 KB
Env Health EJ Readings Week 7.doc31 KB
Midterm key.doc43.5 KB
Ann_Rev_Med.pdf187.71 KB
catalytic efficiency.pdf715.79 KB
Cole XG mouse.pdf149.8 KB
Devel_PharmGen.pdf154.46 KB
Drosophila_08.pdf934.53 KB
Jarvik_CAAD.pdf76.75 KB
shih 1998.pdf339.93 KB
Public Health Ch. 9.pdf2.65 MB
Urinary markers dose calculation.pdf875.11 KB
Spring quarter preview.doc47 KB
Kinetics workshop.xls37.5 KB