The mechanism is believed to be due to the inhibition of prostaglandin synthesis, primarily via inhibition of Cyclooxygenase 2(COX-2).
Celebrex blocks or inhibits the action of the COX -2 enzyme, which plays a key role in pain and inflammation.Celebrex is one of the first COX - 2 specific inhibitions approved for treating pain inflammation and stiffness that accompanies arthritis both osteoarthritis and rheumatoid arthritis.
Celebrex is prescribed for a broad range of painful conditions including Osteoarthritis, Rheumatoid Arthritis, Acute Pain and Primary Dysmenorrhea in adults.
The active ingredient is CYCLOOXYGENASE (COX), an enzyme that produces prostaglandins. Prostaglandins are a class of naturally occurring chemicals that are made in many tissues of the body.They are some of the chemicals that contribute to proper functioning of the stomach and intestinal lining, platelets and kidneys.
failure, hepatitis, menstrual disorders, migraines, pancreatitis, tooth disorders, esophageal perforation, stroke, suicide, Urinary incontinence, urinary tract infections, vaginal problems, vomiting, weakness and weight gain.
CONTRAINDICATIONS:
Don't
take if you are allergic to Sulfonamide drugs such as Sulfadiazin,
Sulfisoxazole, Gatanol and Thiosulfil.Don't
take if you have ASTHMA, face and throat swelling.Don't
take if you are pregnant or breastfeeding.Don't
take in the third trimester.
Don't Take with ACE- inhibitors (blood pressure and heart medication such as Capoten, Vasotec and Prinivil), Aspirin, Coumadin (blood thinning) Fluconazole (Diflucan) and Furosemide (Lasix)
Celebrex is administered in 100, 200 and 400 mg. Doses, usually twice daily.
For Osteoarthritis - 200 mg. Taken as a single dose or in 100 mg. twice daily.
Rheumatoid Arthritis - 100-200 mg twice daily.
Acute Pain and Menstrual Cramps - the starting dose is 400 mg. If needed on the first day- subsequent days, 200mg. Twice daily.
Familial Adenomatous Polyposis - 400 mg twice daily with food- dosage cut in half for people with moderate liver problems.