Week Two: Cell Biology and Cell Membranes
Read pp. 52-71
Objectives:
1. Get a broad picture of the constituents of the cell
2. Understand how proteins get produced
3. Understand how molecules enter and exit the cell
 

CELL BIOLOGY
1. Most cells are capable of performing all of life's basic functions

2. Cells have three subdivision   Fig. 2.7
* cell (plasma) membrane encloses the cell
* nucleus contains genetic information (DNA)
* cytoplasm contains organelles (little organs), cytosol (gelatinous-like liquid) and cytoskeleton (scaffolding)

3. Nucleus      Figs. 2.14-2.17
* gene is a segment of the DNA that codes for a protein
* RNA copies the genetic information from DNA
* ribosomes uses the instructions from RNA to make proteins
* proteins comprised of the 20 amino acids

4. Endoplasmic reticulum    Fig. 2.18
* synthesizes proteins and lipids
* rough ER reticulum is studded with ribosomes
* smooth ER has no ribosomes
Q: is the smooth or rough ER involved in protein synthesis?

5. Golgi apparatus     Fig. 2.19
* modifies proteins and sends them to various locations within and outside the cell
* modifies lipids and carbohydrates

6. Lysosomes
* digest extracellular and intracellular material
* peroxisomes detoxify toxic molecules

7. Mitochondria     Fig. 2.20
* produce the usable form or energy: ATP (adenosine triphosphate)
* convert energy nutrients (carbohydrates, fat and protein) into ATP
* three multi-step processes (glycolysis, Krebs cycle and electron transport chain) are involved in converting glucose to ATP

8. Cytosol contains
* free floating ribosomes
* transport vesicles
* enzymes and other molecules

9. Cytoskeleton is comprised of various proteins involved in  Figs. 2.21-2.22
* supporting the cell structure
* binding cells together
* moving materials within the cell
* moving the cell itself
 

PLASMA (CELL) MEMBRANE

1. Phospholipid bilayer with membrane proteins
* phosphate head is hydrophilic
* lipid tail is hydrophobic
Q: How do phospholipids arrange themselves together

2. This bilayer is a barrier preventing molecules from entering/exiting the cell
* water soluble (hydrophilic) molecules cannot enter unless very small
* lipid soluble (hydrophobic) molecules enter freely unless very big
Q: what type of molecules are hydrophilic?

3. Membrane proteins allow     Fig. 2.8
* transportation of material into the cell
* communication with environment and between cells

4. What determines direction of flow?
* molecules flow down their concentration gradients (from high to low concentration)
* molecules can flow up their gradient if energy is used Fig. 2.11

5. Hydrophobic molecules can flow freely down gradient
* hydrophilic molecules can only flow across if they have a special membrane protein